Which of the following is NOT a sign or symptom of inflammation?

Excessive fatigue is the correct choice as it is not a direct sign or symptom of inflammation. Inflammation is typically characterized by specific local changes known as the cardinal signs: redness, heat, swelling, and pain at the affected site. These signs arise from the body's immune response to injury or infection, leading to increased blood flow, heat production, and pain sensitivity in the area.

While fatigue can often accompany various illnesses and conditions, it is a more general symptom rather than one specifically associated with the inflammatory process itself. Therefore, distinguishing between systemic symptoms like fatigue and localized signs of inflammation helps clarify the nature of the body's response to injury or infection.